Andropatch	Testosterone Complex
Delivery Rates (mg/10cm2/day)	3.3	10.2
Patch Size (cm2)	15 cm2	8 cm2
Enhancers	50% Alcohol	None

In this study, Testosterone was applied as a hydrophilic formulation, in a liquid or dry state, on a ViaDerm treated skin area of 8 cm2. The area under the plasma concentration curve (AUC) was compared to an application of a commercial patch of 15 cm2 (Andropatch) on intact skin. The transdermal delivery rate of the testosterone through ViaDerm treated skin was three times higher in comparison with the Andropatch. This resulted in a higher AUC, despite the fact that the delivery area was much smaller. The advantage of the ViaDerm system is more pronounced taking into account the formulation used in both cases. The commercial formulation contains high amounts of alcohol, which often causes skin irritation. In contrast, the ViaDerm transdermal formulation is completely water based, with no penetration enhancers, causing no skin irritation.